Product References
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages.
International journal of nanomedicine
Luo ZW,Xia K,Liu YW,Liu JH,Rao SS,Hu XK,Chen CY,Xu R,Wang ZX,Xie H
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Mar 09 00:00:00 EST 2021
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Dec 16 00:00:00 EST 2020
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis.
Scientific reports
Utz B,Turpin R,Lampe J,Pouwels J,Klefström J
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Oct 30 00:00:00 EDT 2020
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Cell metabolism
Kurniawan H,Franchina DG,Guerra L,Bonetti L,-Baguet LS,Grusdat M,Schlicker L,Hunewald O,Dostert C,Merz MP,Binsfeld C,Duncan GS,Farinelle S,Nonnenmacher Y,Haight J,Das Gupta D,Ewen A,Taskesen R,Halder R,Chen Y,Jäger C,Ollert M,Wilmes P,Vasiliou V,Harris IS,Knobbe-Thomsen CB,Turner JD,Mak TW,Lohoff M,Meiser J,Hiller K,Brenner D
50-8898 was used in Flow cytometry/Cell sorting to reveal an unexpected role for GSH in restricting serine availability to preserve Treg functionality.
Tue May 05 00:00:00 EDT 2020
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
50-8898 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
ACS nano
Lu J,Liu X,Liao YP,Wang X,Ahmed A,Jiang W,Ji Y,Meng H,Nel AE
50-8898 was used in Flow cytometry/Cell sorting to develop a chemo-immunotherapy approach to reduce the high mortality of metastatic breast cancer, utilising a liposomal carrier to trigger immunogenic cell death.
Tue Nov 27 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Nov 19 00:00:00 EST 2018
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
50-8898 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
50-8898 was used in Flow cytometry/Cell sorting to show that miR-27 has a role in regulating Treg immune cells and that correct control of miR-27 expression is important to safeguard immunological tolerance..
Wed Feb 01 00:00:00 EST 2017
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
50-8898 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.
European journal of immunology
Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L
50-8898 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.
Wed Jun 01 00:00:00 EDT 2016
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Immunohistochemistry
Sat Aug 01 00:00:00 EDT 2015
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Immunohistochemistry
Sat Aug 01 00:00:00 EDT 2015
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
50-8898 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.
Mon Jul 06 00:00:00 EDT 2015
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Nature communications
Mikucki ME,Fisher DT,Matsuzaki J,Skitzki JJ,Gaulin NB,Muhitch JB,Ku AW,Frelinger JG,Odunsi K,Gajewski TF,Luster AD,Evans SS
50-8898 was used in Flow cytometry/Cell sorting to investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma.
Thu Jun 25 00:00:00 EDT 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014