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Invitrogen
Guselkumab Recombinant Human Monoclonal Antibody
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Guselkumab Antibody (MA5-42004) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human IL23A protein expressed in CHO cells using a Guselkumab biosimilar monoclonal antibody (Product # MA5-42004). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42004
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human IL23A
偶联物
形式
Liquid
浓度
2.09 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Guselkumab is a human immunoglobulin G1 lambda (IgG1lambda) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation 2. In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of psoriasis. Developed by Janssen, the subcutaneous injection form of guselkumab was approved in July 2017 under the market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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