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Invitrogen
H4K12me1 Recombinant Rabbit Monoclonal Antibody (RM458)
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产品信息
MA562169
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM458
抗原
A monomethyl-peptide corresponding to monomethyl-Histone H4 (Lys12).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
This antibody reacts to Histone H4 monomethylated at Lysine 12 (K12me1). No cross reactivity with non-modified Lysine 12, or other monomethylations in histone H4.
Predicted to react with all vertebrates.
靶标信息
H4K12me1 refers to the monomethylation of the 12th lysine residue on histone H4, a key post-translational modification involved in the regulation of chromatin structure and gene expression. Histones are proteins that package and order DNA into structural units called nucleosomes, and their modification can influence the accessibility of the DNA to the transcriptional machinery. The monomethylation at H4K12 is associated with both gene activation and repression, depending on the context within the chromatin landscape. This specific histone mark has been implicated in various cellular processes, including DNA repair, replication, and transcriptional regulation. Abnormal patterns of H4K12me1 have been linked to several diseases, including cancer, where they can affect the expression of oncogenes and tumor suppressor genes. Studying H4K12me1 and its regulatory mechanisms provides insights into the epigenetic control of gene expression and offers potential avenues for therapeutic intervention in disease states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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