Invitrogen

H4K20me3 Monoclonal Antibody (6F8-D9)

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H4K20me3 Antibody in Western Blot (WB) — Western blot analysis of Tri-Methyl Histone H4 (Lys20) in Hela cell lysates using a Tri-Methyl Histone H4 (Lys20) monoclonal antibody (Product # MA5-18074) at various dilutions, followed by detection using an AP-conjugated mouse IgG whole molecule antibody at a dilution of 1:2000 on a BCIP/NBT substrate.

产品信息

MA5-18074

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:4,000	-
酶联免疫吸附实验 (ELISA)	Assay-dependent	-
点杂交 (DB)	Assay-dependent	-

产品规格
种属反应	Human, C. elegans
宿主/亚型	Mouse / IgG1
分类	Monoclonal
类型	Antibody
克隆号	6F8-D9
抗原	Synthetic peptide of Human Histone H4
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Protein G
保存液	PBS
内含物	0.1% sodium azide
保存条件	Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
RRID	AB_2539457

产品详细信息

This antibody shows weak cross-reactivity with K20 di-methylated histone H4, but does not react with histone H3 or mono- or unmethylated K20 histone 4. This antibody is predicted to react with Xenopus laevis, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), and mammals.

This target has a predicted molecular weight of 11 kDa.

靶标信息

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: H4 histone family, member A; H4 histone family, member E; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; H4 K20; H4K20; H4Lys20me3; HIST1H4; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 1, H4j; histone 2, H4a; Histone 4; Histone 4 family, member M; histone 4, H4; Histone Cluster 4; histone family member; Histone H2B 2; Histone H4; Histone H4A; Histone H4K20me3; histone IV, family 2; methyl Histone 3; methyl Histone H3; Tri-methyl H4; Tri-methyl Histone H4; Tri-Methyl-H4 K20; Tri-Methyl-H4 Lys20; Tri-Methyl-Histone H4 K20; Tri-Methyl-Histone H4 Lys20; Trimethyl H4; Trimethyl Histone H4

基因别名: CELE_T10C6.11; dJ160A22.2; F07B7.11; F07B7.4; F45F2.12; FO108; H4; H4-16; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4/p; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4F2; H4F2iv; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; his-20; his-22; his-4; his-52; his-54; his-8; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; K06C4.12; K06C4.4; T10C6.11

UniProt ID: (Human) P62805, (C. elegans) Q27894

Entrez Gene ID: (Human) 8359, (Human) 8366, (Human) 8367, (Human) 8294, (Human) 8363, (Human) 8370, (Human) 121504, (C. elegans) 180072

分子生物学功能: histone