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Proteintech
HACE1 Polyclonal Antibody
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产品信息
24104-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HACE1 Fusion Protein Ag21130 (564-909 aa encoded by BC034982)
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RSSCEVVSK ANCAKLKQGI AVRFHGEEGM GQGVVREWFD ILSNEIVNPD YALFTQSADG TTFQPNSNSY VNPDHLNYFR FAGQILGLAL NHRQLVNIYF TRSFYKHILG IPVNYQDVAS IDPEYAKNLQ WILDNDISDL GLELTFSVET DVFGAMEEVP LKPGGGSILV TQNNKAEYVQ LVTELRMTRA IQPQINAFLQ GFHMFIPPSL IQLFDEYELE LLLSGMPEID VSDWIKNTEY TSGYEREDPV IQWFWEVVED ITQEERVLLL QFVTGSSRVP HGGFANIMGG SGLQNFTIAA VPYTPNLLPT SSTCINMLKL PEYPSKEILK DRLLVALHCG SYGYTMA (564-909 aa encoded by BC034982 )
靶标信息
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: E3 ubiquitin-protein ligase HACE1; hace 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
基因别名: HACE1; KIAA1320; SPPRS
UniProt ID: (Human) Q8IYU2
Entrez Gene ID: (Human) 57531
transcription, DNA-templated
regulation of transcription, DNA-templated
Golgi organization
cell cycle
protein ubiquitination
Rac protein signal transduction
regulation of cell migration
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
membrane fusion
protein K48-linked ubiquitination
