Fabgennix

HAND2 Polyclonal Antibody, Biotin

问题与答案

问题与答案

产品信息

HAND2-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to unique amino acid sequences on Heart and neuronal crest derivative protein 2.

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; dHand protein; heart and neural crest derivatives expressed transcript 2; Heart- and neural crest derivatives-expressed protein 2; Helix-loop-helix transcription factor expressed in embryo and deciduum; Thing-2

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基因别名: AI225906; AI661148; BHLHA26; DHAND; DHAND2; Ehand2; HAND2; Hed; Th2; Thing2

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UniProt ID: (Human) P61296, (Rat) P61295, (Mouse) Q61039

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Entrez Gene ID: (Human) 9464, (Rat) 64637, (Mouse) 15111

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RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding AT DNA binding transcription coactivator activity protein binding transcription factor binding activating transcription factor binding protein homodimerization activity transcription regulatory region DNA binding protein heterodimerization activity E-box binding DNA binding sequence-specific DNA binding protein dimerization activity basic helix-loop-helix transcription factor

angiogenesis in utero embryonic development heart looping suckling behavior cardiac right ventricle formation cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation apoptotic process involved in heart morphogenesis noradrenergic neuron differentiation transcription from RNA polymerase II promoter heart development adult heart development mesenchymal cell proliferation positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process regulation of tissue remodeling odontogenesis of dentin-containing tooth embryonic digit morphogenesis negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity tongue development negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development thymus development peripheral nervous system neuron development palate development cartilage morphogenesis coronary artery morphogenesis visceral serous pericardium development cardiac neural crest cell development involved in outflow tract morphogenesis cell proliferation involved in outflow tract morphogenesis positive regulation of ERK1 and ERK2 cascade positive regulation of p38MAPK cascade positive regulation of transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated neural crest cell development cell differentiation negative regulation of apoptotic process mesenchyme development determination of heart left/right asymmetry cellular response to retinoic acid cellular response to organic cyclic compound multicellular organism development