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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • HAND2 Antibodies

          Fabgennix

          HAND2 Polyclonal Antibody, Biotin

          说明书
          实验方案
          问题与答案
          技术支持
          说明书
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          Cite HAND2 Polyclonal Antibody, Biotin

          产品信息

          HAND2-BIOTIN

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          -

          免疫组化 (IHC)

          1:50-1:250
          -

          酶联免疫吸附实验 (ELISA)

          1:10,000
          -

          免疫沉淀 (IP)

          1:50-1:250
          -
          产品规格

          种属反应

          Human, Mouse, Non-human primate, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide corresponding to unique amino acid sequences on Heart and neuronal crest derivative protein 2.

          偶联物

          Biotin Biotin Biotin

          形式

          Liquid

          浓度

          0.5-1.5 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; dHand protein; heart and neural crest derivatives expressed transcript 2; Heart- and neural crest derivatives-expressed protein 2; Helix-loop-helix transcription factor expressed in embryo and deciduum; Thing-2

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          基因别名: AI225906; AI661148; BHLHA26; DHAND; DHAND2; Ehand2; HAND2; Hed; Th2; Thing2

          查看更多 收起

          UniProt ID: (Human) P61296, (Rat) P61295, (Mouse) Q61039

          查看更多 收起

          Entrez Gene ID: (Human) 9464, (Rat) 64637, (Mouse) 15111

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          功能
          RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding AT DNA binding transcription coactivator activity protein binding transcription factor binding activating transcription factor binding protein homodimerization activity transcription regulatory region DNA binding protein heterodimerization activity E-box binding DNA binding sequence-specific DNA binding protein dimerization activity basic helix-loop-helix transcription factor
          参与通路
          angiogenesis in utero embryonic development heart looping suckling behavior cardiac right ventricle formation cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation apoptotic process involved in heart morphogenesis noradrenergic neuron differentiation transcription from RNA polymerase II promoter heart development adult heart development mesenchymal cell proliferation positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process regulation of tissue remodeling odontogenesis of dentin-containing tooth embryonic digit morphogenesis negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity tongue development negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development thymus development peripheral nervous system neuron development palate development cartilage morphogenesis coronary artery morphogenesis visceral serous pericardium development cardiac neural crest cell development involved in outflow tract morphogenesis cell proliferation involved in outflow tract morphogenesis positive regulation of ERK1 and ERK2 cascade positive regulation of p38MAPK cascade positive regulation of transcription regulatory region DNA binding positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated neural crest cell development cell differentiation negative regulation of apoptotic process mesenchyme development determination of heart left/right asymmetry cellular response to retinoic acid cellular response to organic cyclic compound multicellular organism development
          It has to be done as per old AB suggested Products section.
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