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Invitrogen
HCoV-NL63 Spike S1/S2 Recombinant Rabbit Monoclonal Antibody (279)
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产品信息
MA5-60552
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
279
抗原
Recombinant HCoV-NL63 Spike S1/S2 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recognize the Spike of HCoV-NL63 in ELISA. Doesn't recognize the Spike of SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, HCoV-HKU1 (isolate N5), HCoV-OC43.. Has cross-reactivity in ELISA with: HCoV-NL63 Spike S1+S2 ECD-His; No cross-reactivity in ELISA with: SARS-CoV-2 Spike S1-His; SARS-CoV-2 Spike S1 NTD-Fc & AVI; SARS-CoV-2 Spike S1 NTD-His & AVI; SARS-CoV-2 Spike RBD-His; SARS-CoV-2 Spike S1+S2 ECD-His; SARS-CoV-2 Spike S2 ECD-His; SARS-CoV Spike S1+S2 ECD-His; MERS-CoV Spike S1+S2 ECD-His; HCoV-229E Spike S1+S2 ECD-His; HCoV-OC43 Spike S1+S2 ECD-His; HCoV-HKU1 (isolate N5) Spike S1+S2 ECD-His
靶标信息
HCoV-NL63 Spike S1/S2 refers to the specific regions of the spike (S) protein of the Human Coronavirus NL63 (HCoV-NL63), which is a virus known to cause respiratory infections, including the common cold, particularly in children, the elderly, and immunocompromised individuals. The spike protein is essential for viral entry into host cells and is composed of two subunits: S1, which contains the receptor-binding domain (RBD) responsible for attaching to the host cell receptor angiotensin-converting enzyme 2 (ACE2), and S2, which facilitates the fusion of the viral and host cell membranes. The S1/S2 cleavage site is a critical juncture where host proteases cleave the spike protein, activating it for membrane fusion and subsequent viral entry. Understanding the structure and function of these regions is crucial for developing targeted therapies and vaccines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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