Product References
Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate-Based Rat Model of Gulf War Illness.
The Journal of pharmacology and experimental therapeutics
Ribeiro-Davis A,Al Saeedy DY,Jahr FM,Hawkins E,McClay JL,Deshpande LS
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Wed Jan 17 00:00:00 UTC 2024
HDAC1-mediated regulation of GABA signaling within the lateral septum facilitates long-lasting social fear extinction in male mice.
Translational psychiatry
Bludau A,Neumann ID,Menon R
PA1-860 was used in Western Blotting to show that HDAC1-mediated regulation of GABA signaling in the LS is crucial for the formation of long-lasting social fear extinction memory.
Tue Jan 17 00:00:00 UTC 2023
CREB inactivation by HDAC1/PP1γ contributes to dopaminergic neurodegeneration in Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xu ¿¿¿ X,He ¿¿ X,Zhang ¿¿¿ Z,Chen ¿¿¿ Y,Li ¿¿¿ J,Ma ¿¿¿ S,Huang ¿¿¿ Q,Li ¿¿¿ M
PA1-860 was used in Proximity Ligation Assay to suggest that disruption of the CREB/HDAC1 interaction to restore CREB activity may be a potential therapeutic approach in PD.
Fri Apr 29 00:00:00 UTC 2022
PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation.
Disease markers
Luo J,Li J,Li T,Zhang Z,Chen G,Li Q,Qi H,Si Z
PA1-860 was used in ChIP Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that the NFATc1/HDAC1/IRF-1/p38 MAPK signaling axis is highlighted as a promising therapeutic target for potentiating hepatoprotective effects of PIAS1 against HIRI.
Tue Sep 13 00:00:00 UTC 2022
Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.
Nature communications
Litke C,Hagenston AM,Kenkel AK,Paldy E,Lu J,Kuner R,Mauceri D
PA1-860 was used in Immunohistochemistry to discover that the organic anion transporter OAT1 provides a molecular link between nociceptive activity, epigenetic-regulated transcription, and spinal sensitization.
Tue Feb 15 00:00:00 UTC 2022
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner.
Nature communications
Paniagua I,Tayeh Z,Falcone M,Hernández Pérez S,Cerutti A,Jacobs JJL
PA1-860 was used in Antibody array to conclude that MAD2L2 suppresses aberrant nucleolytic processing both at DSBs and stalled replication forks by differentially engaging shieldin and REV1/REV3L, respectively.
Thu Sep 08 00:00:00 UTC 2022
Epstein-Barr virus nuclear antigen 3C (EBNA3C) interacts with the metabolism sensing C-terminal binding protein (CtBP) repressor to upregulate host genes.
PLoS pathogens
Ohashi M,Hayes M,McChesney K,Johannsen E
PA1-860 was used in ChIP assay to suggest that CtBP is bound to these promoters in the absence of EBNA3C and that EBNA3C interaction with CtBP interferes with the repressive function of CtBP, leading to EBNA3C mediated upregulation.
Mon Mar 01 00:00:00 UTC 2021
Epstein-Barr virus nuclear antigen 3C (EBNA3C) interacts with the metabolism sensing C-terminal binding protein (CtBP) repressor to upregulate host genes.
PLoS pathogens
Ohashi M,Hayes M,McChesney K,Johannsen E
PA1-860 was used in ChIP assay to suggest that CtBP is bound to these promoters in the absence of EBNA3C and that EBNA3C interaction with CtBP interferes with the repressive function of CtBP, leading to EBNA3C mediated upregulation.
Mon Mar 01 00:00:00 UTC 2021
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.
Respiratory research
Lüdtke TH,Wojahn I,Kleppa MJ,Schierstaedt J,Christoffels VM,Künzler P,Kispert A
PA1-860 was used in Immunoprecipitation to suggest that TBX2 interacts with homeobox and HMG-box transcription factors as well as with the NuRD chromatin remodeling complex to repress transcription of anti-proliferative genes in the pulmonary mesenchyme.
Wed Mar 17 00:00:00 UTC 2021
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.
Respiratory research
Lüdtke TH,Wojahn I,Kleppa MJ,Schierstaedt J,Christoffels VM,Künzler P,Kispert A
PA1-860 was used in Immunoprecipitation to suggest that TBX2 interacts with homeobox and HMG-box transcription factors as well as with the NuRD chromatin remodeling complex to repress transcription of anti-proliferative genes in the pulmonary mesenchyme.
Wed Mar 17 00:00:00 UTC 2021
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.
Respiratory research
Lüdtke TH,Wojahn I,Kleppa MJ,Schierstaedt J,Christoffels VM,Künzler P,Kispert A
PA1-860 was used in Immunoprecipitation to suggest that TBX2 interacts with homeobox and HMG-box transcription factors as well as with the NuRD chromatin remodeling complex to repress transcription of anti-proliferative genes in the pulmonary mesenchyme.
Wed Mar 17 00:00:00 UTC 2021
Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain.
Frontiers in cellular neuroscience
Guo F,Zhang YF,Liu K,Huang X,Li RX,Wang SY,Wang F,Xiao L,Mei F,Li T
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunocytochemistry
Tue Sep 14 00:00:00 UTC 2021
Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain.
Frontiers in cellular neuroscience
Guo F,Zhang YF,Liu K,Huang X,Li RX,Wang SY,Wang F,Xiao L,Mei F,Li T
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunocytochemistry
Tue Sep 14 00:00:00 UTC 2021
Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition.
BMC cancer
Ramaker RC,Hardigan AA,Gordon ER,Wright CA,Myers RM,Cooper SJ
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP Assay
Sat May 29 00:00:00 UTC 2021
Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition.
BMC cancer
Ramaker RC,Hardigan AA,Gordon ER,Wright CA,Myers RM,Cooper SJ
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP Assay
Sat May 29 00:00:00 UTC 2021
LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase.
Cells
Sobczak M,Strachowska M,Gronkowska K,Karwaciak I,Pułaski Ł,Robaszkiewicz A
PA1-860 was used in Immunoprecipitation to show that activation of toll-like receptors with bacterial components such as LPS is accompanied by the decline in transcription of hydrogen peroxide decomposing enzyme-catalase, suppression of which facilitates the polarization of human macrophages towards the pro-inflammatory phenotype.
Sat Sep 18 00:00:00 UTC 2021
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies.
EMBO molecular medicine
Wu CC,Jin LW,Wang IF,Wei WY,Ho PC,Liu YC,Tsai KJ
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Mon Jun 08 00:00:00 UTC 2020
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies.
EMBO molecular medicine
Wu CC,Jin LW,Wang IF,Wei WY,Ho PC,Liu YC,Tsai KJ
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Mon Jun 08 00:00:00 UTC 2020
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies.
EMBO molecular medicine
Wu CC,Jin LW,Wang IF,Wei WY,Ho PC,Liu YC,Tsai KJ
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Mon Jun 08 00:00:00 UTC 2020
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Nature communications
Pao PC,Patnaik D,Watson LA,Gao F,Pan L,Wang J,Adaikkan C,Penney J,Cam HP,Huang WC,Pantano L,Lee A,Nott A,Phan TX,Gjoneska E,Elmsaouri S,Haggarty SJ,Tsai LH
PA1-860 was used in Immunohistochemistry to demonstrate pharmacological activation of HDAC1 alleviates the deleterious effects of 8-oxoG in aged wild-type and 5XFAD mice.
Mon May 18 00:00:00 UTC 2020
The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Nature communications
Iershov A,Nemazanyy I,Alkhoury C,Girard M,Barth E,Cagnard N,Montagner A,Chretien D,Rugarli EI,Guillou H,Pende M,Panasyuk G
PA1-860 was used in Western Blotting to study the role of class 3 PI3K in the regulation of autophagy and mitochnondrial lipid metabolism.
Fri Apr 05 00:00:00 UTC 2019
Neuroepigenetic signatures of age and sex in the living human brain.
Nature communications
Gilbert TM,Zürcher NR,Catanese MC,Tseng CJ,Di Biase MA,Lyall AE,Hightower BG,Parmar AJ,Bhanot A,Wu CJ,Hibert ML,Kim M,Mahmood U,Stufflebeam SM,Schroeder FA,Wang C,Roffman JL,Holt DJ,Greve DN,Pasternak O,Kubicki M,Wey HY,Hooker JM
PA1-860 was used in Western Blotting to measure in vivo expression of the epigenetic enzymes, histone deacetylases, across healthy human aging and between sexes using [11C]Martinostat positron emission tomography (PET) neuroimaging.
Wed Jul 03 00:00:00 UTC 2019
HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.
iScience
Patel N,Wang J,Shiozawa K,Jones KB,Zhang Y,Prokop JW,Davenport GG,Nihira NT,Hao Z,Wong D,Brandsmeier L,Meadows SK,Sampaio AV,Werff RV,Endo M,Capecchi MR,McNagny KM,Mak TW,Nielsen TO,Underhill TM,Myers RM,Kondo T,Su L
PA1-860 was used in Western Blotting to uncover a new HDAC2-dependent pathway that integrates reversible acetylation signaling to the anticancer ubiquitin response.
Fri Mar 29 00:00:00 UTC 2019
Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.
Redox biology
Tempka D,Tokarz P,Chmielewska K,Kluska M,Pietrzak J,Rygielska Ż,Virág L,Robaszkiewicz A
PA1-860 was used in Chromatin immunoprecipitation to demonstrate that CDK4/6 inhibitors sensitise G1-arrested cells to anticancer drugs, since these cells require poly(ADP-ribose) polymerase 1-8-oxoguanine glycosylase functional interaction for cell survival.
Tue May 01 00:00:00 UTC 2018
Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Vidaurre OG,Adula KP,Kezunovic N,Wentling M,Huntley GW,Casaccia P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunofluorescence
Wed Aug 02 00:00:00 UTC 2017
Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Vidaurre OG,Adula KP,Kezunovic N,Wentling M,Huntley GW,Casaccia P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunofluorescence
Wed Aug 02 00:00:00 UTC 2017
Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Vidaurre OG,Adula KP,Kezunovic N,Wentling M,Huntley GW,Casaccia P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunofluorescence
Wed Aug 02 00:00:00 UTC 2017
Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li X,Eberhardt A,Hansen JN,Bohmann D,Li H,Schor NF
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Thu Jun 01 00:00:00 UTC 2017
Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1.
The Journal of steroid biochemistry and molecular biology
Patrick NM,Griggs CA,Icenogle AL,Gilpatrick MM,Kadiyala V,Jaime-Frias R,Smith CL
PA1-860 was used in Western Blotting to demonstrate that Class I lysine deacetylases facilitate dexamethasone-induced transcriptional repression by suppressing LSD1 complex activity at selected target gene promoters.
Wed Mar 01 00:00:00 UTC 2017
Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway.
Molecular medicine reports
Gao M,Chen T,Wu L,Zhao X,Mao H,Xing C
PA1-860 was used in Western Blotting to study the effect and mechanism of pioglitazone on the calcification of rat vascular smooth muscle cells.
Wed Nov 01 00:00:00 UTC 2017
Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.
Scientific reports
Wiśnik E,Płoszaj T,Robaszkiewicz A
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Fri Aug 25 00:00:00 UTC 2017
Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.
Scientific reports
Wiśnik E,Płoszaj T,Robaszkiewicz A
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Fri Aug 25 00:00:00 UTC 2017
Loss of Asxl2 leads to myeloid malignancies in mice.
Nature communications
Li J,He F,Zhang P,Chen S,Shi H,Sun Y,Guo Y,Yang H,Man N,Greenblatt S,Li Z,Guo Z,Zhou Y,Wang L,Morey L,Williams S,Chen X,Wang QT,Nimer SD,Yu P,Wang QF,Xu M,Yang FC
PA1-860 was used in Western Blotting to demonstrate that ASXenopus laevis2 functions as a tumour suppressor to maintain normal haematopoietic stem cell function.
Thu Jun 08 00:00:00 UTC 2017
Lactate's effect on human neuroblastoma cell bioenergetic fluxes.
Biochemical pharmacology
E L,Swerdlow RH
PA1-860 was used in western blot to investigate how lactate affects neuron metabolism
Fri Jan 01 00:00:00 UTC 2016
The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation.
PloS one
Dubey A,Copeland PR
PA1-860 was used in Immunocytochemistry-immunoflourescence to argue for two distinct pools of eEFSec in the cell, where the cytoplasmic pool participates in Sec incorporation and the nuclear pool may be involved in an as yet unknown function.
Wed Jun 28 00:00:00 UTC 2017
HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zimberlin CD,Lancini C,Sno R,Rosekrans SL,McLean CM,Vlaming H,van den Brink GR,Bots M,Medema JP,Dannenberg JH
PA1-860 was used in western blot to investigate the role of HDAC1 and HDAC2 in intestinal homeostasis
Fri May 01 00:00:00 UTC 2015
Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression.
ASN neuro
Lebrun-Julien F,Suter U
PA1-860 was used in immunohistochemistry - paraffin section to determine the functional role of HDAC1 and HDAC2 in an acute model of optic nerve injury.
Mon Feb 15 00:00:00 UTC 2016
Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor.
Molecular cell
Kim JY,Kwak PB,Weitz CJ
PA1-860 was used in western blot to investigate how different NuRD subunits regulate the PER complex.
Thu Dec 18 00:00:00 UTC 2014
RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing.
Nucleic acids research
Khan DH,Gonzalez C,Cooper C,Sun JM,Chen HY,Healy S,Xu W,Smith KT,Workman JL,Leygue E,Davie JR
PA1-860 was used in immunoprecipitation and western blot to study the modulation of MCL1 alternative splicing by an RNA-dependent mechanism involving dynamic histone acetylation
Sat Feb 01 00:00:00 UTC 2014
Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions.
Nature structural & molecular biology
Morris SA,Baek S,Sung MH,John S,Wiench M,Johnson TA,Schiltz RL,Hager GL
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Wed Jan 01 00:00:00 UTC 2014
HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jacob C,Lötscher P,Engler S,Baggiolini A,Varum Tavares S,Brügger V,John N,Büchmann-Møller S,Snider PL,Conway SJ,Yamaguchi T,Matthias P,Sommer L,Mantei N,Suter U
PA1-860 was used in ChIP assay, immunohistochemistry, and western blot to study the roles of Pax3, Sox10 and Fabp7 in the mechanism by which HDAC-1 and -2 control the specification of neural crest cells into peripheral glia
Wed Apr 23 00:00:00 UTC 2014
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Reinhardt S,Schuck F,Grösgen S,Riemenschneider M,Hartmann T,Postina R,Grimm M,Endres K
PA1-860 was used in western blot to study the regulation of ADAM10 expression by the unfolded protein response transcription factor XBP-1 and the implications for Alzheimer's disease
Sat Feb 01 00:00:00 UTC 2014
Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation.
Neurobiology of aging
E L,Burns JM,Swerdlow RH
PA1-860 was used in western blot to determine how intensive exercise affects brain bioenergetics, inflammation, and neurogenesis-relevant parameters
Sat Nov 01 00:00:00 UTC 2014
Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.
The Journal of biological chemistry
Yokoyama A,Igarashi K,Sato T,Takagi K,Otsuka I M,Shishido Y,Baba T,Ito R,Kanno J,Ohkawa Y,Morohashi K,Sugawara A
PA1-860 was used in western blot to study the role of MyT1 as a component of an LSD-1 complex specific to neural cells
Fri Jun 27 00:00:00 UTC 2014
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Nature neuroscience
Dobbin MM,Madabhushi R,Pan L,Chen Y,Kim D,Gao J,Ahanonu B,Pao PC,Qiu Y,Zhao Y,Tsai LH
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Aug 01 00:00:00 UTC 2013
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Nature neuroscience
Dobbin MM,Madabhushi R,Pan L,Chen Y,Kim D,Gao J,Ahanonu B,Pao PC,Qiu Y,Zhao Y,Tsai LH
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Aug 01 00:00:00 UTC 2013
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Nature neuroscience
Dobbin MM,Madabhushi R,Pan L,Chen Y,Kim D,Gao J,Ahanonu B,Pao PC,Qiu Y,Zhao Y,Tsai LH
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Aug 01 00:00:00 UTC 2013
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Nature neuroscience
Dobbin MM,Madabhushi R,Pan L,Chen Y,Kim D,Gao J,Ahanonu B,Pao PC,Qiu Y,Zhao Y,Tsai LH
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Aug 01 00:00:00 UTC 2013
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Nature neuroscience
Dobbin MM,Madabhushi R,Pan L,Chen Y,Kim D,Gao J,Ahanonu B,Pao PC,Qiu Y,Zhao Y,Tsai LH
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Aug 01 00:00:00 UTC 2013
Lactate administration reproduces specific brain and liver exercise-related changes.
Journal of neurochemistry
E L,Lu J,Selfridge JE,Burns JM,Swerdlow RH
PA1-860 was used in immunohistochemistry to study the ability of exogenous lactate to recapitulate some of the liver and brain changes associated with exercise
Tue Oct 01 00:00:00 UTC 2013
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program.
The Journal of biological chemistry
Lin S,Shen H,Li JL,Tang S,Gu Y,Chen Z,Hu C,Rice JC,Lu J,Wu L
PA1-860 was used in western blot to study the mechanism by which SFMBT1 modulates epigenetic silencing and mitogenic gene expression
Fri Mar 01 00:00:00 UTC 2013
Protein kinase CK2 regulates the dimerization of histone deacetylase 1 (HDAC1) and HDAC2 during mitosis.
The Journal of biological chemistry
Khan DH,He S,Yu J,Winter S,Cao W,Seiser C,Davie JR
PA1-860 was used in immunocytochemistry, immunoprecipitation, and western blot to study the modulation of the dimerization of HDAC-1 and -2 by CK2-mediated phosphorylation during mitosis
Fri Jun 07 00:00:00 UTC 2013
Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.
Leukemia
Maiques-Diaz A,Chou FS,Wunderlich M,Gómez-López G,Jacinto FV,Rodriguez-Perales S,Larrayoz MJ,Calasanz MJ,Mulloy JC,Cigudosa JC,Alvarez S
PA1-860 was used in ChIP assay to investigate the importance of Sp1 in functional chromatin modifications induced by AML1-ETO
Fri Jun 01 00:00:00 UTC 2012
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4.
Proceedings of the National Academy of Sciences of the United States of America
Sailaja BS,Cohen-Carmon D,Zimmerman G,Soreq H,Meshorer E
PA1-860 was used in immunoprecipitation to study the role of HDAC4 in mediating stress-associated epigenetic changes in acetylcholinesterase transcription and splicing
Wed Dec 26 00:00:00 UTC 2012
Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide.
British journal of cancer
Chang J,Varghese DS,Gillam MC,Peyton M,Modi B,Schiltz RL,Girard L,Martinez ED
PA1-860 was used in western blot to investigate the effects of trichostatin A and depsipeptide on cancer cells
Tue Jan 03 00:00:00 UTC 2012
Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
Oncogene
Gu Y,Lin S,Li JL,Nakagawa H,Chen Z,Jin B,Tian L,Ucar DA,Shen H,Lu J,Hochwald SN,Kaye FJ,Wu L
PA1-860 was used in western blot to study the role of LKB1/CREB-regulated transcription co-activator signaling in esophageal cancer cell migration and invasion
Thu Jan 26 00:00:00 UTC 2012
Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wu M,Hernandez M,Shen S,Sabo JK,Kelkar D,Wang J,O'Leary R,Phillips GR,Cate HS,Casaccia P
PA1-860 was used in immunoprecipitation to study the role of histone acetylation in the different effects on the oligodendrocyte transcriptome of sonic hedgehog and BMP4
Wed May 09 00:00:00 UTC 2012
Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.
Pharmaceuticals (Basel, Switzerland)
Sleiman SF,Berlin J,Basso M,Karuppagounder SS,Rohr J,Ratan RR
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Mon Aug 22 00:00:00 UTC 2011
Identification of a gene regulatory network necessary for the initiation of oligodendrocyte differentiation.
PloS one
Swiss VA,Nguyen T,Dugas J,Ibrahim A,Barres B,Androulakis IP,Casaccia P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Thu Apr 07 00:00:00 UTC 2011
Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.
Journal of biomedicine & biotechnology
Best AM,Chang J,Dull AB,Beutler JA,Martinez ED
PA1-860 was used in western blot to investigate potential epigenetic modulators
Fri Jul 15 00:00:00 UTC 2011
Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.
Molecular biology of the cell
Wang X,He S,Sun JM,Delcuve GP,Davie JR
PA1-860 was used in western blot to investigate the role of peroxiredoxin 1 in the pathogenesis of estrogen receptor negative breast cancer
Wed Sep 01 00:00:00 UTC 2010
EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells.
BMC molecular biology
Wang H,Gambosova K,Cooper ZA,Holloway MP,Kassai A,Izquierdo D,Cleveland K,Boney CM,Altura RA
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Western Blot
Tue Aug 31 00:00:00 UTC 2010
Ageing-related chromatin defects through loss of the NURD complex.
Nature cell biology
Pegoraro G,Kubben N,Wickert U,Göhler H,Hoffmann K,Misteli T
PA1-860 was used in immunocytochemistry and western blot to investigate the important roles of NURD remodeling complex in aging
Thu Oct 01 00:00:00 UTC 2009
Ageing-related chromatin defects through loss of the NURD complex.
Nature cell biology
Pegoraro G,Kubben N,Wickert U,Göhler H,Hoffmann K,Misteli T
PA1-860 was used in immunocytochemistry and western blot to investigate the important roles of NURD remodeling complex in aging
Thu Oct 01 00:00:00 UTC 2009
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Nature neuroscience
Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Mon Sep 01 00:00:00 UTC 2008
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Nature neuroscience
Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Mon Sep 01 00:00:00 UTC 2008
Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem.
Neuron
Magnusson AK,Park TJ,Pecka M,Grothe B,Koch U
PA1-860 was used in immunohistochemistry to study the role of retrograde GABA signaling in adjusting sound localization
Thu Jul 10 00:00:00 UTC 2008
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain.
The Journal of cell biology
Shen S,Li J,Casaccia-Bonnefil P
PA1-860 was used in immunohistochemistry and western blot to demonstrate the role of histone modifications in oligodendrocyte progenitor differentiation during rat brain.
Mon May 23 00:00:00 UTC 2005
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain.
The Journal of cell biology
Shen S,Li J,Casaccia-Bonnefil P
PA1-860 was used in immunohistochemistry and western blot to demonstrate the role of histone modifications in oligodendrocyte progenitor differentiation during rat brain.
Mon May 23 00:00:00 UTC 2005
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain.
The Journal of cell biology
Shen S,Li J,Casaccia-Bonnefil P
PA1-860 was used in immunohistochemistry and western blot to demonstrate the role of histone modifications in oligodendrocyte progenitor differentiation during rat brain.
Mon May 23 00:00:00 UTC 2005
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
Molecular and cellular biology
Duan Z,Zarebski A,Montoya-Durango D,Grimes HL,Horwitz M
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Dec 01 00:00:00 UTC 2005
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
Molecular and cellular biology
Duan Z,Zarebski A,Montoya-Durango D,Grimes HL,Horwitz M
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Dec 01 00:00:00 UTC 2005
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
Molecular and cellular biology
Duan Z,Zarebski A,Montoya-Durango D,Grimes HL,Horwitz M
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in Immunoprecipitation
Thu Dec 01 00:00:00 UTC 2005
Differential intranuclear organization of transcription factors Sp1 and Sp3.
Molecular biology of the cell
He S,Sun JM,Li L,Davie JR
PA1-860 was used in immunocytochemistry to study the nuclear localization of transcription factors Sp1 and Sp3.
Thu Sep 01 00:00:00 UTC 2005
Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins.
The Journal of biological chemistry
Di-Poï N,Desvergne B,Michalik L,Wahli W
PA1-860 was used in western blot to study the relationship between PPARbeta and C/EBP transcription factors and its effect on cell proliferation and differentiation.
Fri Nov 18 00:00:00 UTC 2005
Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins.
The Journal of biological chemistry
Di-Poï N,Desvergne B,Michalik L,Wahli W
PA1-860 was used in western blot to study the relationship between PPARbeta and C/EBP transcription factors and its effect on cell proliferation and differentiation.
Fri Nov 18 00:00:00 UTC 2005
Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation.
Biochimica et biophysica acta
Sanders JA,Gruppuso PA
PA1-860 was used in western blot to investigate the localization of hepatic c-Myc in the nucleolus and its functional significance
Tue Mar 22 00:00:00 UTC 2005
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.
Nucleic acids research
Ling Y,Sankpal UT,Robertson AK,McNally JG,Karpova T,Robertson KD
PA1-860 was used in western blot to study the regulation of DNA methyltransferase Dnmt3a enzymatic activity and transcriptional regulation.
Wed Apr 21 00:00:00 UTC 2004
Mitogen- and stress-activated protein kinase 1 activity and histone h3 phosphorylation in oncogene-transformed mouse fibroblasts.
Cancer research
Drobic B,Espino PS,Davie JR
PA1-860 was used in western blot to study the effect of mitogen- and stress-activated protein kinase 1 on histone H3 phosphorylation.
Wed Dec 15 00:00:00 UTC 2004
Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat.
Journal of virology
Lu H,Pise-Masison CA,Linton R,Park HU,Schiltz RL,Sartorelli V,Brady JN
PA1-860 was used in chromatin immunoprecipitation to study the effect of HTLV-1 viral transcriptional activator Tax on transcriptional regulation.
Thu Jul 01 00:00:00 UTC 2004
Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome.
Molecular and cellular biology
Morrison AJ,Sardet C,Herrera RE
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Fri Feb 01 00:00:00 UTC 2002
Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome.
Molecular and cellular biology
Morrison AJ,Sardet C,Herrera RE
Published figure using HDAC1 polyclonal antibody (Product # PA1-860) in ChIP assay
Fri Feb 01 00:00:00 UTC 2002
Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.
Molecular and cellular biology
Yochum GS,Ayer DE
PA1-860 was used in western blot to investigate the role of Pf1 in the two global transcription networks, mSin3A and TLE.
Sun Jul 01 00:00:00 UTC 2001
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.jpg?time=20220826?time=20220826 "HDAC1 Antibody (PA1-860) in WB")
.jpg?time=20220826?time=20220826 "HDAC1 Antibody (PA1-860) in WB")
.jpg?time=20220826?time=20220826 "HDAC1 Antibody (PA1-860) in WB")
.jpg?time=20220826?time=20220826 "HDAC1 Antibody (PA1-860) in WB")
