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产品信息
MA5-18069
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:400-1:800 | - |
免疫细胞化学 (ICC/IF) |
Assay-dependent | - |
免疫沉淀 (IP) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Mouse / IgG2a |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
3G6 |
抗原 |
Human C-terminal peptide, aa 411-428 (NEFYDGDHDNDKESDVEI) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Protein G |
保存液 |
PBS |
内含物 |
0.1% sodium azide |
保存条件 |
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID |
AB_2539452 |
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45
基因别名: AW537363; HD3; HDAC3; RPD3; RPD3-2
UniProt ID: (Human) O15379, (Mouse) O88895
Entrez Gene ID: (Human) 8841, (Mouse) 15183
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
regulation of mitotic cell cycle
chromatin modification
histone deacetylation
regulation of protein stability
positive regulation of TOR signaling
negative regulation of interleukin-1 production
negative regulation of tumor necrosis factor production
circadian regulation of gene expression
regulation of multicellular organism growth
positive regulation of transcription factor import into nucleus
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of protein export from nucleus
spindle assembly
cellular response to fluid shear stress
positive regulation of type B pancreatic cell apoptotic process
negative regulation of cardiac muscle cell differentiation
circadian rhythm
negative regulation of myotube differentiation
negative regulation of apoptotic process
cellular lipid metabolic process
histone H3 deacetylation
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
transcription factor binding
enzyme binding
cyclin binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
histone deacetylase binding
NF-kappaB binding
DNA binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
chromatin DNA binding
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
GTPase binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
