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Proteintech
HDAC4 Polyclonal Antibody
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产品信息
17449-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HDAC4 Fusion Protein Ag11572 (623-972 aa encoded by BC039904)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calculated molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140 kDa.
Immunogen sequence: SKKLLGSLA SVFVRLPCGG VGVDSDTIWN EVHSAGAARL AVGCVVELVF KVATGELKNG FAVVRPPGHH AEESTPMGFC YFNSVAVAAK LLQQRLSVSK ILIVDWDVHH GNGTQQAFYS DPSVLYMSLH RYDDGNFFPG SGAPDEVGTG PGVGFNVNMA FTGGLDPPMG DAEYLAAFRT VVMPIASEFA PDVVLVSSGF DAVEGHPTPL GGYNLSARCF GYLTKQLMGL AGGRIVLALE GGHDLTAICD ASEACVSALL GNELDPLPEK VLQQRPNANA VRSMEKVMEI HSKYWRCLQR TTSTAGRSLI EAQTCENEEA ETVTAMASLS VGVKPAEKRP DEEPMEEEPP L (623-972 aa encoded by BC039904)
靶标信息
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp779K1053; HD4; HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR
基因别名: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288
UniProt ID: (Human) P56524
Entrez Gene ID: (Human) 9759
RNA polymerase III transcription factor binding
core promoter binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
transcription factor binding
zinc ion binding
protein kinase binding
potassium ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
activating transcription factor binding
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast development
chromatin remodeling
transcription, DNA-templated
inflammatory response
nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of lamellipodium assembly
negative regulation of myotube differentiation
regulation of cardiac muscle contraction by calcium ion signaling
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
positive regulation of smooth muscle cell migration
chromatin modification
histone deacetylation
B cell differentiation
positive regulation of protein sumoylation
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
B cell activation
response to drug
regulation of protein binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
negative regulation of osteoblast differentiation
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
regulation of skeletal muscle fiber development
positive regulation of sequence-specific DNA binding transcription factor activity
response to interleukin-1
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
positive regulation of reactive oxygen species biosynthetic process
