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Leinco Technologies
HER-2 (Trastuzumab) Recombinant Human Monoclonal Antibody (4D5-8)
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产品信息
LT1500-1MG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4D5-8
抗原
Human epidermoid carcinoma cells (A431) over-expressing EGFR.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
≥5.0 mg/mL
规格
1 mg
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
no preservative
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Specificity: This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Trastuzumab. Clone 4D5-8 recognizes human erbB-2. This product is for research use only.
Endotoxin Level: ≤ 1.0 EU/mg as determined by the LAL method. Purity: ≥95% monomer by analytical SEC.
Product Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Pathogen Testing: To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage and Handling: Functional grade biosimilar antibodies may be stored sterile as received at 2-8 C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80 C. Avoid Repeated Freeze Thaw Cycles.
This antibody has been tested in the following applications: Immunohistochemistry, Flow Cytometry, ELISA, CyTOF®.
靶标信息
ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: approximately 68 kDa secreted autoinhibitor glycoprotein; c-erb B2/neu protein; CD antigen CD340; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene Neu; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
基因别名: c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2
UniProt ID: (Human) P04626
Entrez Gene ID: (Human) 2064
RNA polymerase I core binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
receptor binding
protein binding
ATP binding
coreceptor activity
growth factor binding
receptor tyrosine kinase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
cell proliferation
Schwann cell development
peptidyl-tyrosine phosphorylation
neuron differentiation
positive regulation of cell growth
regulation of microtubule-based process
positive regulation of Rho protein signal transduction
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-EGFR signaling pathway
ERBB2-ERBB4 signaling pathway
wound healing
regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
positive regulation of JNK cascade
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
semaphorin-plexin signaling pathway
positive regulation of protein targeting to membrane
neurotransmitter receptor localization to postsynaptic specialization membrane
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