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Proteintech
HEXA Monoclonal Antibody (3A4F2)
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产品信息
60337-1-IG
产品规格
种属反应
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
3A4F2
抗原
HEXA Fusion Protein Ag1854 (1-529 aa encoded by BC018927)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.86 mg/mL
规格
279 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MTSSRLWFS LLLAAAFAGR ATALWPWPQN FQTSDQRYVL YPNNFQFQYD VSSAAQPGCS VLDEAFQRYR DLLFGSGSWP RPYLTGKRHT LEKNVLVVSV VTPGCNQLPT LESVENYTLT INDDQCLLLS ETVWGALRGL ETFSQLVWKS AEGTFFINKT EIEDFPRFPH RGLLLDTSRH YLPLSSILDT LDVMAYNKLN VFHWHLVDDP SFPYESFTFP ELMRKGSYNP VTHIYTAQDV KEVIEYARLR GIRVLAEFDT PGHTLSWGPG IPGLLTPCYS GSEPSGTFGP VNPSLNNTYE FMSTFFLEVS SVFPDFYLHL GGDEVDFTCW KSNPEIQDFM RKKGFGEDFK QLESFYIQTL LDIVSSYGKG YVVWQEVFDN KVKIQPDTII QVWREDIPVN YMKELELVTK AGFRALLSAP WYLNRISYGP DWKDFYVVEP LAFEGTPEQK ALVIGGEACM WGEYVDNTNL VPRLWPRAGA VAERLWSNKL TSDLTFAYER LSHFRCELLR RGVQAQPLNV GFCEQEFEQT (1-529 aa encoded by BC018927)
靶标信息
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-hexosaminidase; beta-hexosaminidase alpha-subunit; Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; EC 3.2.1; EC 3.2.1.52; glycosidase; HEXA; hexosaminidase A (alpha polypeptide); hexosaminidase A (alpha polypeptide) isoform HEXA_1; hexosaminidase A (alpha polypeptide) isoform HEXA_2; hexosaminidase A (alpha polypeptide) isoform HEXA_3; hexosaminidase A (alpha polypeptide) isoform HEXA_4; hexosaminidase A (alpha polypeptide) isoform HEXA_5; Hexosaminidase subunit A; Hexose aminidase A (alpha polypeptide); MGC99608; N-acetyl-alpha-glucosaminidase prepro-polypeptide; N-acetyl-beta-glucosaminidase subunit alpha; Unknown; unnamed protein product
基因别名: Hex-1; HEXA; TSD
UniProt ID: (Human) P06865, (Mouse) P29416, (Rat) Q641X3
Entrez Gene ID: (Rabbit) 100008950, (Human) 3073, (Mouse) 15211, (Rat) 300757
skeletal system development
carbohydrate metabolic process
glycosaminoglycan biosynthetic process
N-glycan processing
lipid metabolic process
ganglioside catabolic process
lysosome organization
sensory perception of sound
locomotory behavior
adult walking behavior
lipid storage
sexual reproduction
glycosaminoglycan metabolic process
dermatan sulfate catabolic process
hyaluronan catabolic process
myelination
cell morphogenesis involved in neuron differentiation
neuromuscular process controlling posture
neuromuscular process controlling balance
carbohydrate derivative metabolic process
metabolic process
SMAD protein signal transduction
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