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Invitrogen
HIF1AN Polyclonal Antibody
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HIF1AN Antibody (PA5-19456) in WB
Western blot analysis of HeLa Whole Cell Lysate using Product # PA5-19456, HIF1AN primary antibody at a dilution of 1 µg/mL (lane 1). Staining of Jurkat Whole Cell Lysate at a dilution of 1 µg/mL (lane 2). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.
产品信息
PA5-19456
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from within residues 250 to the C-terminus of Human FIH/asparagine hydroxylase.
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA5-19456 targets HIF1AN in IF and WB applications and shows reactivity with Human samples.
The PA5-19456 immunogen is synthetic peptide derived from within residues 250 to the C-terminus of Human FIH/asparagine hydroxylase.
PA5-19456 detects HIF1AN which has a predicted molecular weight of approximately 40 kDa.
靶标信息
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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