Invitrogen

HIRA Polyclonal Antibody

Name: HIRA Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-68807

查看其他6个HIRA抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

PA5-68807

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1.0 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of mouse HIRA

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2688882

产品详细信息

This target displays homology in the following species: Dog: 79%; Guinea Pig: 93%; Horse: 79%; Human: 86%; Mouse: 100%; Rabbit: 93%; Rat: 100%

靶标信息

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。