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Immunogen sequence: EASSPDYFGPP AKNGVAAEVS PAKEENPRRA SKAVEESSDE ERQRDLPAQR GEESSEEEEK GYKGKTRKKP VVKKQAPGKA SVSRKQA
Highest antigen sequence identity to the following orthologs - mouse 41%, rat 43%.
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HIRA-interacting protein 3
基因别名: HIRIP3
UniProt ID: (Human) Q9BW71
Entrez Gene ID: (Human) 8479