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Immunogen sequence: ATYNLDEEN RFRTLKWLIS PVKIVSRPTI RQGHGENRQR EIEIRFDQLH REYCLSPRNQ PRRMCLPDSW AMNMYRGGPA SPGGLQGLET RRLSLPSSKA KAKSLSEAFE NLGKRSLEAG RCLPKSDSSS SLPKTNPTHS ATRPQQTSDL HVQGNSSGIF RKSVSPSKTL SVPDKEVPGH GRNRYDEIKE EFDKLHQKYC LKSPGQMTVP LCIGVSTDKA SMEVRYQTEG FLGKLNPDPH FQGFQKLPSS PLGCRKSLLG STAIEAPSST CVARAITRDG TRDHQFPAKR PRLSEPQGSG RQGNSLGASD GVDNTVRPGD QGSSSQPNSE ERGENTSYRM EEKSDFMLEK LETKSV (394-748 aa encoded by BC001940)
Holliday junction recognition protein (HJURP) is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. It acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. HJURP prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. It directly binds to Holliday junctions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 14-3-3-associated AKT substrate; fetal liver expressing gene 1; Fetal liver-expressing gene 1 protein; Holliday junction recognition protein; Up-regulated in lung cancer 9
基因别名: FAKTS; FLEG1; hFLEG1; HJURP; URLC9
UniProt ID: (Human) Q8NCD3
Entrez Gene ID: (Human) 55355