Search
Invitrogen
HLA-DQA1/HLA-DPA1/HLA-DRB1 Recombinant Rabbit Monoclonal Antibody (K01_3P85)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 2
HLA-DQA1/HLA-DPA1/HLA-DRB1 Antibody (MA566799) in WB
Western Blot analysis of HLA-DQA1/HLA-DPA1/HLA-DRB1 in Raji using HLA-DQA1/HLA-DPA1/HLA-DRB1 Recombinant Monoclonal Antibody (Product # MA566799). 15 µg of Raji lysate was run on 6-18% SDS-PAGE under reducing conditions and blotted onto nitrocellulose membrane. HLA-DQA1/HLA-DPA1/HLA-DRB1 Recombinant Monoclonal Antibody (Product # MA566799) was used as the primary antibody and peroxidase conjugated goat anti... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA566799
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_3P85
抗原
A synthesized peptide derived from human HLA-DQA1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.97 mg/mL
规格
97 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
HLA-DQA1, HLA-DPA1, and HLA-DRB1 encode key alpha and beta chain components of the human leukocyte antigen (HLA) class II system, which presents extracellularly derived peptides to CD4+ T helper cells and orchestrates adaptive immune responses. HLA-DQA1 pairs with HLA-DQB1 to form HLA-DQ, HLA-DPA1 pairs with HLA-DPB1 to form HLA-DP, and HLA-DRB1 pairs with HLA-DRA to form HLA-DR; among these, HLA-DRB1 is the most polymorphic class II gene and a major determinant of peptide-binding specificity. Extensive allelic diversity across these loci underlies interindividual variation in antigen presentation, influences susceptibility to autoimmune diseases (e.g., type 1 diabetes, celiac disease, rheumatoid arthritis), infection outcomes, and responses to vaccines, and is central to donor-recipient matching in transplantation. Expression is predominantly on professional antigen-presenting cells (dendritic cells, B cells, macrophages) and is induced by interferon-y via the CIITA transactivator. Structural variation and specific epitope motifs (such as the DRB1 "shared epitope") modulate T-cell tolerance and pathogenic T-cell activation, while linkage disequilibrium across the class II region forms common haplotypes with combined functional effects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DC-1 alpha chain; DC-alpha; DP(W3); DP(W4); DP-A1; DQ-A1; DR-B1; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DCA; HLA-DP alpha 1; HLA-DQ alpha 1; HLA-DR beta 1; HLA-DRB1; HLA-SB alpha chain; Human leukocyte antigen DRB1; MHC class II DP3-alpha; MHC class II DPA1; MHC class II DQA1
基因别名: HLA-DP1A; HLA-DPA1; HLA-DQA1; HLA-DRB1; HLASB
Entrez Gene ID: (Human) 3113, (Human) 3117, (Human) 3123
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
