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Immunogen sequence: DTRPRFLEY STSECHFFNG TERVRFLDRY FHNQEENVRF DSDVGEFRAV TELGRPDAEY WNSQKDILED ERAAVDTYCR HNYGVGESFT VQRRVHPKVT VYPSKTQPLQ HHNLLVCSVS GFYPGSIEVR WFRNGQEEKT GVVSTGLIHN GDWTFQTLVM LETVPRSGEV YTCQVEHPSV TSPLTVEWRA RSESAQSK (31-227 aa encoded by BC007920 )
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; lymphocyte antigen DRB1; MHC class II antigen; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta
基因别名: DRB1; DRw10; HLA-DR1B; HLA-DRB; HLA-DRB1; SS1
UniProt ID: (Human) Q4PRC3
Entrez Gene ID: (Human) 3123