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Invitrogen
HLA-G-0104 Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA562567
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HLA-G-0104 is a non-classical major histocompatibility complex (MHC) class I molecule and is an important member of the HLA-G gene family known for its immunomodulatory properties. It plays a crucial role in immune tolerance during pregnancy transplant acceptance and tumor immune evasion. HLA-G's involvement in modulating the immune system is primarily facilitated through its interaction with inhibitory receptors on immune cells such as ILT-2 and ILT-4 which helps in suppressing the activity of natural killer (NK) and T cells. This specific allele HLA-G0104 is part of a family of isoforms with both membrane-bound and soluble forms contributing to its functional diversity. Research indicates that HLA-G0104 could be involved in regulating responses in autoimmune diseases and cancer reflecting its potential as a target for therapeutic interventions aimed at enhancing immune tolerance or boosting anti-tumor immunity. Understanding the structural and functional aspects of HLA-G-0104 is vital for developing strategies that leverage its immune-inhibitory capabilities for clinical benefits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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