Recommended positive controls: NT2D1.
Predicted reactivity: Mouse (85%), Rat (86%), Rhesus Monkey (98%).
IHC (P): suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
蛋白别名: homer homolog 3; Homer protein homolog 3; Homer, neuronal immediate early gene, 3; Homer-3; VASP/Ena-related gene up-regulated during seizure and LTP 3; Vesl-3
基因别名: HOMER-3; HOMER3; Vesl-3; VESL3
分子生物学功能: scaffold/adaptor protein