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Recommended positive controls: NT2D1.
Predicted reactivity: Mouse (85%), Rat (86%), Rhesus Monkey (98%).
IHC (P): suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: homer homolog 3; Homer protein homolog 3; Homer, neuronal immediate early gene, 3; Homer-3; VASP/Ena-related gene up-regulated during seizure and LTP 3; Vesl-3
基因别名: HOMER-3; HOMER3; Vesl-3; VESL3
UniProt ID: (Human) Q9NSC5, (Rat) Q9Z2X5
Entrez Gene ID: (Human) 9454, (Rat) 29548
分子生物学功能:
scaffold/adaptor protein