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产品信息
PA5-64911
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human HOXA11 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2662777 |
产品详细信息
Immunogen sequence: LPQVQPVREVT FREYAIEPAT KWHPRGNLAH CYSAEELVHR DCLQAPSAAG VPGDVLAKSS ANVYHHPTPA VSSNFYSTVG RNGVLPQAFD QF
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
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生物信息学
蛋白别名: homeo box 1I; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11
基因别名: HOX1; HOX1I; HOXA11; RUSAT1
UniProt ID: (Human) P31270
Entrez Gene ID: (Human) 3207
分子生物学功能:
homeodomain transcription factor
skeletal system development
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
transcription, DNA-templated
multicellular organism development
spermatogenesis
single fertilization
mesodermal cell fate specification
male gonad development
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
positive regulation of cell development
embryonic limb morphogenesis
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
developmental growth
uterus development
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
