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Invitrogen
HRK Polyclonal Antibody
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产品信息
PA1-86773
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
15 amino acid peptide from near the centre of human HRK
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blot, this antibody detects a band at ~13 kDa in mouse pancreas tissue lysate.
Rabbit anti HRK antibody detects Harakiri (HRK), also known as Neuronal death protein DP5 or BH3-interacting domain-containing protein 3. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis.
靶标信息
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activator of apoptosis harakiri; activator of apoptosis Hrk; BCL2-interacting protein; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); Neuronal death protein DP5
基因别名: AI838259; BID3; DP5; HARAKIRI; HRK
UniProt ID: (Human) O00198, (Rat) P62817, (Mouse) P62816
Entrez Gene ID: (Human) 8739, (Rat) 117271, (Mouse) 12123
apoptotic process
positive regulation of protein homooligomerization
positive regulation of apoptotic process
positive regulation of release of cytochrome c from mitochondria
regulation of apoptotic process
positive regulation of neuron apoptotic process
cellular response to potassium ion starvation
