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Invitrogen
HS6ST1 Polyclonal Antibody
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HS6ST1 Antibody (PA5-48068) in WB
Western blot analysis of HS6ST1 in H4 human neuroglioma cell line. Samples were incubated in HS6ST1 polyclonal antibody (Product # PA5-48068) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for HS6ST1 at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-48068
产品规格
种属反应
Human
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHO-derived recombinant human HS6ST1 Pro28-Trp401
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, less than 1% cross-reactivity with recombinant mouse HS6ST3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
The HS6ST1 gene encodes the enzyme heparan sulfate 6-O-sulfotransferase 1, which is essential for the biosynthesis of heparan sulfate (HS) glycosaminoglycans by adding sulfate groups to the 6th position of glucosamine residues within HS chains. HS6ST1 is vital for numerous biological processes, including modulating the activity of growth factors, cytokines, and chemokines, which are influenced by HS structures on the cell surface and extracellular matrix. This sulfation step is critical for the proper functioning of developmental pathways and neuronal signaling, impacting brain development and function. Mutations in HS6ST1 have been associated with intellectual disabilities and developmental disorders such as hypogonadotropic hypogonadism and Kallmann syndrome, characterized by impaired sense of smell and delayed puberty. Moreover, altered HS6ST1 expression is implicated in cancer progression by affecting tumor growth, angiogenesis, and metastasis through altered HS interactions with signaling molecules. Its role in modulating receptor-ligand interactions makes HS6ST1 a promising target for therapeutic interventions aimed at repairing defective signaling pathways associated with genetic disorders and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HS6ST-1
基因别名: HH15; HS6ST; HS6ST1
UniProt ID: (Human) O60243
Entrez Gene ID: (Human) 9394
