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HSP90 Antibody (MA5-45104) in IHC (P)
Immunohistochemistry analysis using backskin. Fixation involved Bouins Fixative and paraffin-embedded. Samples were incubated with Hsp90 monoclonal antibody (Product # MA5-45104) at 1:100 for 1 hour at RT, followed by FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Epidermis.
产品信息
MA5-45104
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Chicken,
Fish,
Hamster,
Human,
Mouse,
Rabbit,
Rat,
Shark
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
H9010
抗原
Recombinant human HSP90beta
偶联物
激发/发射光谱
482/675 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
47.35mM phosphate/2.15mM MES, pH 7.2, with 2mM EDTA, 0.17066µM Pentachlorophenol, 0.8mM ethanol
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2931558
产品详细信息
1 µg/mL of MA5-45104 was sufficient for detection of HSP90beta in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects 90kDa. Detects HSP90 beta in all reactive species except in Chicken, where it detects both alpha and beta isoforms.
靶标信息
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90 kDa alpha class B member 1; heat shock protein 90A; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP84; HSP86; hsp90 beta; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen
基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPC3; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; I79_004665; LAP-2; LAP2
ATP binding
protein C-terminus binding
ATPase activity
nitric-oxide synthase regulator activity
estrogen receptor binding
TPR domain binding
heat shock protein binding
progesterone receptor binding
identical protein binding
virion binding
unfolded protein binding
chaperone binding
Hsp90 protein binding
disordered domain specific binding
nucleotide binding
UTP binding
CTP binding
mRNA binding
protein tyrosine kinase activity
protein binding
GTP binding
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
dATP binding
protein homodimerization activity
histone deacetylase binding
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
double-stranded RNA binding
protein kinase regulator activity
kinase binding
cadherin binding involved in cell-cell adhesion
protein dimerization activity
Hsp90 family chaperone
protein folding
positive regulation of cell proliferation
response to heat
response to cold
response to organonitrogen compound
response to organic cyclic compound
response to progesterone
cellular response to heat
positive regulation of nitric oxide biosynthetic process
response to antibiotic
regulation of catalytic activity
protein stabilization
positive regulation of cell cycle G2/M phase transition
G2/M transition of mitotic cell cycle
neuron migration
skeletal muscle contraction
mitochondrial transport
receptor-mediated endocytosis
response to unfolded protein
signal transduction
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
peptidyl-tyrosine phosphorylation
regulation of protein ubiquitination
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
protein refolding
regulation of protein complex assembly
protein unfolding
response to estrogen
protein import into mitochondrial outer membrane
positive regulation of cell size
vascular endothelial growth factor receptor signaling pathway
regulation of nitric-oxide synthase activity
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
regulation of cellular response to heat
placenta development
virion attachment to host cell
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
negative regulation of neuron apoptotic process
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to interleukin-4
cellular response to organic cyclic compound
positive regulation of protein serine/threonine kinase activity
fibril organization
cell-cell adhesion
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell cycle arrest
negative regulation of transforming growth factor beta activation
nitric oxide biosynthetic process
response to stress
positive regulation of cytotoxic T cell differentiation
