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HSP90 total Monoclonal Antibody (4F3.E8)

查看其他31个HSP90抗体

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产品信息

200-301-F74

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

10 µg/mL
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4F3.E8

抗原

Hsp90 total Antibody was produced in mice by repeated immunizations raised against recombinant Human Hsp90 purified from E.coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 90kDa heat shock protein; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP84; HSP86; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen; unnamed protein product

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基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; Hsp103; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPC3; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2

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UniProt ID: (Human) P07900, (Human) P08238, (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Human) 3320, (Human) 3326, (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252

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功能
nucleotide binding UTP binding CTP binding RNA binding mRNA binding protein binding ATP binding GTP binding hydrolase activity ATPase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding ubiquitin protein ligase binding dATP binding identical protein binding protein homodimerization activity histone deacetylase binding protein binding involved in protein folding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding unfolded protein binding DNA polymerase binding scaffold protein binding disordered domain specific binding ATP-dependent protein folding chaperone enzyme-substrate adaptor activity protein tyrosine kinase binding double-stranded RNA binding protein kinase regulator activity kinase binding protein kinase binding heat shock protein binding peptide binding ATP-dependent protein binding cadherin binding protein dimerization activity protein phosphatase activator activity receptor ligand inhibitor activity histone methyltransferase binding poly(A) RNA binding Hsp90 family chaperone
参与通路
neuron migration activation of innate immune response positive regulation of defense response to virus by host skeletal muscle contraction protein folding mitochondrial transport response to unfolded protein telomere maintenance via telomerase response to heat response to cold response to xenobiotic stimulus response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process protein import into mitochondrial matrix regulation of protein ubiquitination positive regulation of telomere maintenance via telomerase positive regulation of protein polymerization positive regulation of interferon-beta production regulation of protein localization cellular response to heat protein refolding response to cocaine positive regulation of protein import into nucleus regulation of apoptotic process regulation of protein complex assembly protein unfolding response to estrogen positive regulation of nitric oxide biosynthetic process positive regulation of protein catabolic process positive regulation of cell size nitric oxide metabolic process response to antibiotic protein stabilization chaperone-mediated protein complex assembly positive regulation of cardiac muscle contraction chaperone-mediated autophagy cellular response to virus regulation of postsynaptic membrane neurotransmitter receptor levels neurofibrillary tangle assembly telomerase holoenzyme complex assembly placenta development virion attachment to host cell positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of apoptotic process positive regulation of cell differentiation regulation of cell cycle cellular response to interleukin-4 fibril organization negative regulation of proteasomal protein catabolic process positive regulation of protein localization to cell surface nitric oxide biosynthetic process response to stress positive regulation of protein import into nucleus, translocation protein import into mitochondrial outer membrane positive regulation of cytotoxic T cell differentiation regulation of catalytic activity positive regulation of protein binding negative regulation of neuron apoptotic process positive regulation of protein serine/threonine kinase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to organic cyclic compound
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