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Invitrogen
HSPA1A Monoclonal Antibody (K40046_8C11)
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HSPA1A Antibody (MA5-55917) in IHC (P)
Immunohistochemistry analysis of HSPA1A in paraffin-embedded testis tissue. Sample was incubated with HSPA1A monoclonal antibody (Product # MA5-55917) at a dilution of 5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-55917
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K40046_8C11
抗原
Recombinant human HSPA1A (immunogen range is 351-600).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: QDFFNGRDLN KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
靶标信息
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; epididymis secretory sperm binding protein; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock protein family A member 1A; heat shock-induced protein; HSP70-1/HSP70-2; HSP70.1/HSP70.2; unnamed protein product
基因别名: HEL-S-103; HSP70; HSP70-1; HSP70-1A; HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1
UniProt ID: (Human) P0DMV8
Entrez Gene ID: (Human) 3303
G-protein coupled receptor binding
transcription corepressor activity
RNA binding
receptor binding
protein binding
ATP binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
histone deacetylase binding
protein binding involved in protein folding
cadherin binding
receptor agonist activity
misfolded protein binding
C3HC4-type RING finger domain binding
disordered domain specific binding
transcription regulator inhibitor activity
ATP-dependent protein disaggregase activity
negative regulation of transcription from RNA polymerase II promoter
mRNA catabolic process
response to unfolded protein
lysosomal transport
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of cell growth
negative regulation of transforming growth factor beta receptor signaling pathway
endoplasmic reticulum unfolded protein response
regulation of protein ubiquitination
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of interleukin-8 production
positive regulation of RNA splicing
cellular response to oxidative stress
cellular response to heat
cellular response to unfolded protein
protein refolding
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of erythrocyte differentiation
ATP metabolic process
protein stabilization
chaperone-mediated protein complex assembly
cellular heat acclimation
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to steroid hormone stimulus
positive regulation of microtubule nucleation
negative regulation of inclusion body assembly
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitotic spindle assembly
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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