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PA1-31842 detects HSPB8 from human samples.
PA1-31842 has been successfully used in Western blot applications.
The PA1-31842 immunogen is: Peptide with sequence NELPQDSQEVTCT, from C Terminus of the protein sequence according to NP_055180
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。