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Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Monkey, Bovine, Elephant, Horse, Rabbit, Guinea pig, Platypus (94%); Dog, Bat (88%); Rat, Panda (81%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
5-HT1F is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. 5-HT1F is a member of the GPCR family. Expression of 5-HT1F has been reported in various brain structures, including cortex, hippocampus, trigeminal ganglia, and cerebral blood vessels. Expression in peripheral tissues is limited to uterus, mesentery, and artery. No expression has been detected in heart, kidney, liver, pancreas, or spleen.
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蛋白别名: 5-HT-1F; 5-HT1f receptor; 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled; 5-hydroxytryptamine receptor 1F; 5HT1F Receptor; Serotonin receptor 1F
基因别名: 5-HT-1F; 5-HT1F; 5HT6; HTR1EL; HTR1F; MR77
UniProt ID: (Human) P30939
Entrez Gene ID: (Human) 3355
分子生物学功能: G-protein coupled receptor