Leinco Technologies

Hepsin Monoclonal Antibody (3H10.1), Functional Grade, In Vivo GOLD™

Name: Hepsin Monoclonal Antibody (3H10.1), Functional Grade, In Vivo GOLD\u2122
Brand: Leinco Technologies
SKU: H5500-100MG

查看其他7个Hepsin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

H5500-100MG

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

3H10.1

抗原

Human hepsin protein

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

≥5.0 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.2-7.4

内含物

no preservative

保存条件

4°C short term, -80°C long term

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Specificity: Clone 3H10.1.2 is able to recognize full-length native Hepsin expressed on the cell surface in addition to the recombinant soluble form.

Endotoxin Level: <1.0 EU/mg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.

靶标信息

Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。