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Proteintech
Hexokinase 2 Monoclonal Antibody (2A11C3), CoraLite® 594
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产品信息
CL594-66974
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2A11C3
抗原
Hexokinase 2 fusion protein Ag16895
偶联物
激发/发射光谱
593/614 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: HGTGDELFDH IVQCIADFLE YMGMKGVSLP LGFTFSFPCQ QNSLDESILL KWTKGFKASG CEGEDVVTLL KEAIHRREEF DLDVVAVVND TVGTMMTCGF EDPHCEVGLI VGTGSNACYM EEMRNVELVE GEEGRMCVNM EWGAFGDNGC LDDFRTEFDV AVDELSLNPG KQRFEKMISG MYLGEIVRNI LIDFTKRGLL FRGRISERLK TRGIFETKFL SQIESDCLAL LQVRAILQHL GLESTCDDSI IVKEVCTVVA RRAAQLCGAG MAAVVDRIRE NRGLDALKVT VGVDGTLYKL HPHFAKVMHE TVKDLAPKCD VSFLQSEDGS GKGAALITAV ACRIREAGQR
靶标信息
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686M1669; Hexokinase; Hexokinase type II; Hexokinase-2; hexokinase-2 muscle; hexokinase-2, muscle; Hexokinase-B; HK II; Muscle form hexokinase; OTTHUMP00000202738
基因别名: AI642394; HK2; HKII; HXK2
UniProt ID: (Human) P52789, (Mouse) O08528, (Rat) P27881
Entrez Gene ID: (Human) 3099, (Mouse) 15277, (Rat) 25059
cellular glucose homeostasis
response to ischemia
glycolytic process
lactation
apoptotic mitochondrial changes
glucose transport
negative regulation of mitochondrial membrane permeability
regulation of glucose import
carbohydrate phosphorylation
glucose 6-phosphate metabolic process
canonical glycolysis
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
positive regulation of mitophagy in response to mitochondrial depolarization
negative regulation of reactive oxygen species metabolic process
carbohydrate metabolic process
glucose metabolic process
metabolic process
phosphorylation
glucose catabolic process
