Invitrogen

Histone Core Polyclonal Antibody

Name: Histone Core Polyclonal Antibody
Brand: Invitrogen
SKU: PA1-28375

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

PA1-28375

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫沉淀 (IP)

1:20

产品规格

种属反应

Bovine

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Intact calf histone core - rRNA complex.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.42 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_1957612

产品详细信息

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The histone core is an integral component of chromatin structure, consisting of an octamer of core histones: H2A, H2B, H3, and H4. Each nucleosome unit contains two copies of each of these histones, forming a structural foundation around which approximately 147 base pairs of DNA are wrapped. The histone octamer is organized with an (H3-H4)2 tetramer at its core, flanked by two H2A-H2B dimers. This highly conserved structure not only facilitates DNA compaction but also plays a critical role in regulating gene expression through various post-translational modifications, such as acetylation, methylation, and phosphorylation. These modifications can alter chromatin dynamics and accessibility, impacting processes such as transcription, replication, and DNA repair. The presence of specific histone variants further adds to the epigenetic complexity and regulation of the genome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。