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产品信息
PEP-1438
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 18 amino acid peptide near the amino terminus of human ABCA7.
PEP-1438 can be used as a blocking peptide with polyclonal antibody PA5-34396.
靶标信息
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ABCA-SSN; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; Autoantigen SS-N; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025; Macrophage ABC transporter; Phospholipid-transporting ATPase ABCA7
基因别名: ABCA-SSN; ABCA7; ABCX; AD9
UniProt ID: (Human) Q8IZY2
Entrez Gene ID: (Human) 10347
分子生物学功能:
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
phagocytosis
memory
positive regulation of cholesterol efflux
phospholipid scrambling
peptide cross-linking
negative regulation of ATPase activity
positive regulation of ATPase activity
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
positive regulation of phagocytosis
transmembrane transport
positive regulation of ERK1 and ERK2 cascade
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
positive regulation of phospholipid efflux
