Invitrogen

Human DR5 (aa 255-270) Synthetic Peptide

产品信息

PEP-048

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Lyophilized
浓度	0.5 mg/mL
纯化类型	purified
内含物	no preservative
保存条件	-20° C, Avoid Freeze/Thaw Cycles

产品详细信息

PEP-048 is a 17 amino acid synthetic peptide whose sequence corresponds to residues 255-270 of human DR5. The sequence of this peptide is (amino to carboxy terminus): C-V255-P-E-Q-E-M-E-V-Q-E-P-A-E-P-T-G270 (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human DR5 sequence)

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and DR5, catalog # PA1-957. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

Reconstitute with 0.1 mL of distilled water.

靶标信息

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; dr-5; Fas-like protein; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; Tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9

基因别名: CD262; DR5; KILLER; KILLER/DR5; TNFRSF10B; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; UNQ160/PRO186; ZTNFR9

UniProt ID: (Human) O14763

Entrez Gene ID: (Human) 8795

分子生物学功能: transmembrane signal receptor