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产品信息
PEP-0079
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 16 amino acids near the carboxy terminus of human FLASH.
PEP-0079 can be used as a blocking peptide with polyclonal antibody PA5-19954.
靶标信息
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; FLASH homolog RIP25; FLICE associated huge; FLICE-associated huge protein; FLJ11208; human FLASH; RP11-63K6.3
基因别名: CASP8AP2; CED-4; FLASH; KIAA1315; RIP25
UniProt ID: (Human) Q9UKL3
Entrez Gene ID: (Human) 9994
分子生物学功能:
protein-binding activity modulator
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
Fas signaling pathway
cellular response to mechanical stimulus
apoptotic signaling pathway
negative regulation of nucleic acid-templated transcription
