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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属 |
Human |
表达系统 |
Human |
分子量 |
58.9 kDa |
分类 |
Native |
类型 |
Protein |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
6.7 mg/mL |
纯化类型 |
purified |
保存液 |
50% water with 50% glycerol |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RP-43072 contains native human Factor X protein purified from blood/plasma.
RP-43072 may be used as a positive control in many immunological assays.
The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!
F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activated factor Xa heavy chain; Coagulation factor X; Factor 10; Factor X heavy chain; Factor X light chain; factor Xa; Factor10; prothrombinase; RP11-98F14.9; Stuart factor; Stuart-Prower factor
基因别名: F10; FX; FXA
UniProt ID: (Human) P00742
Entrez Gene ID: (Human) 2159
分子生物学功能:
serine protease
