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产品信息
PEP-0566
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 13 amino acids near the carboxy terminus of human Grik2.
PEP-0566 can be used as a blocking peptide with polyclonal antibody PA5-20449.
靶标信息
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GluK2; GLUR 6; GluR-6; glutamate receptor; Glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 2; GRIK 2; GRIK2 protein
基因别名: EAA4; GLR6; GluK2; GLUK6; GLUR6; GRIK2; MRT6
UniProt ID: (Human) Q13002
Entrez Gene ID: (Human) 2898
分子生物学功能:
transmembrane signal receptor
behavioral fear response
transport
cellular calcium ion homeostasis
intracellular protein transport
glutamate receptor signaling pathway
chemical synaptic transmission
neuronal action potential
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
