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产品信息
PEP-0937
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 19 amino acids near the amino terminus of human IA-1.
PEP-0937 can be used as a blocking peptide with polyclonal antibody PA5-20823.
靶标信息
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: insulinoma associated 1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1
基因别名: IA-1; IA1; INSM1
UniProt ID: (Human) Q01101
Entrez Gene ID: (Human) 3642
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
type B pancreatic cell differentiation
pancreatic A cell differentiation
type B pancreatic cell development
noradrenergic neuron development
transcription, DNA-templated
cell cycle
negative regulation of cell proliferation
regulation of gene expression
positive regulation of cell migration
endocrine pancreas development
norepinephrine biosynthetic process
regulation of protein complex assembly
positive regulation of cell differentiation
transdifferentiation
adrenal chromaffin cell differentiation
sympathetic ganglion development
positive regulation of cell cycle arrest
positive regulation of neural precursor cell proliferation
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
cyclin binding
chromatin DNA binding
histone deacetylase binding
metal ion binding
