Invitrogen

Human IRF3 Synthetic Peptide

产品信息

PEP-0204

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 14 amino acids near the carboxy terminus of human IRF3.

PEP-0204 can be used as a blocking peptide with polyclonal antibody PA5-20086.

靶标信息

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Interferon regulatory factor 3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3

基因别名: IIAE7; IRF3

UniProt ID: (Human) Q14653

Entrez Gene ID: (Human) 3661

分子生物学功能: winged helix/forkhead transcription factor

功能

negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus lipopolysaccharide-mediated signaling pathway negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA type I interferon biosynthetic process positive regulation of cytokine secretion defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway cellular response to dsRNA macrophage apoptotic process programmed necrotic cell death

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription cofactor activity protein binding identical protein binding protein homodimerization activity

Human IRF3 Synthetic Peptide

产品信息

PEP-0204

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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