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产品信息
PEP-1496
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 19 amino acids near the carboxy terminus of human KEAP1.
PEP-1496 can be used as a blocking peptide with polyclonal antibody PA5-34454.
靶标信息
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19
基因别名: INRF2; KEAP1; KIAA0132; KLHL19
UniProt ID: (Human) Q14145
Entrez Gene ID: (Human) 9817
分子生物学功能:
scaffold/adaptor protein
in utero embryonic development
selenium compound metabolic process
malate metabolic process
transcription, DNA-templated
flavonoid metabolic process
response to metal ion
proteasomal ubiquitin-independent protein catabolic process
negative regulation of gene expression
protein ubiquitination
alkanesulfonate metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to immobilization stress
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
cytoplasmic sequestering of transcription factor
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of epidermal cell differentiation
protein oligomerization
cellular response to interleukin-4
cellular response to organic cyclic compound
response to thyroid hormone
