Invitrogen

Human MC4R Synthetic Peptide

产品信息

PEP-0873

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 19 amino acids near the amino terminus of human MC4R.

PEP-0873 can be used as a blocking peptide with polyclonal antibody PA5-20759.

靶标信息

Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: MC4; MC4 receptor; MC4-R; Melanocortin receptor 4

基因别名: MC4R

UniProt ID: (Human) P32245

Entrez Gene ID: (Human) 4160

分子生物学功能: G-protein coupled receptor

功能

diet induced thermogenesis energy reserve metabolic process adenylate cyclase-modulating G-protein coupled receptor signaling pathway feeding behavior insulin secretion positive regulation of cAMP biosynthetic process response to insulin positive regulation of bone resorption negative regulation of feeding behavior regulation of grooming behavior

参与通路

melanocortin receptor activity melanocyte-stimulating hormone receptor activity protein binding peptide hormone binding ubiquitin protein ligase binding neuropeptide binding

Human MC4R Synthetic Peptide

产品信息

PEP-0873

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

性能保障

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