Invitrogen

Human MD-2 Synthetic Peptide

产品信息

PEP-0177

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 13 amino acids near the middle region of human MD-2.

PEP-0177 can be used as a blocking peptide with polyclonal antibody PA5-20058.

靶标信息

Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ESOP-1; Ly-96; Lymphocyte antigen 96; myeloid differentiation protein-2; Protein MD-2

基因别名: ESOP-1; ESOP1; ly-96; LY96; MD-2; MD2

UniProt ID: (Human) Q9Y6Y9

Entrez Gene ID: (Human) 23643

分子生物学功能: scaffold/adaptor protein

功能

MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway inflammatory response cellular defense response cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide detection of lipopolysaccharide positive regulation of tumor necrosis factor production negative regulation of MyD88-independent toll-like receptor signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway innate immune response necroptotic process apoptotic signaling pathway

参与通路

lipopolysaccharide receptor activity protein binding coreceptor activity

Human MD-2 Synthetic Peptide

产品信息

PEP-0177

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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