Invitrogen

Human NALP12 Synthetic Peptide

产品信息

PEP-1141

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 18 amino acids near the amino terminus of human NALP12.

PEP-1141 can be used as a blocking peptide with polyclonal antibody PA5-21027.

靶标信息

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: monarch 1; Monarch-1; NACHT, LRR and PYD domains-containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide

基因别名: CLR19.3; FCAS2; NALP12; NLRP12; PAN6; PYPAF7; RNO; RNO2

UniProt ID: (Human) P59046

Entrez Gene ID: (Human) 91662

功能

参与通路

protein binding ATP binding cysteine-type endopeptidase activator activity involved in apoptotic process

Human NALP12 Synthetic Peptide

产品信息

PEP-1141

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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