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产品信息
PEP-123
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.5 mg/mL |
纯化类型 |
purified |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
产品详细信息
PEP-123 is a 17 amino acid synthetic peptide whose sequences are derived from human NFAT5 protein. The sequence of this peptide is (amino to carboxy terminus): C-D (1439)-L-L-V-S-L-Q-N-Q-G-N-N-L-T-G-S-F (1455)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human NFAT5, catalog # PA1-023. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glutamine rich protein H65; NF-AT5; NFAT-like protein 1; Nuclear factor of activated T-cells 5; osmotic response element-binding protein; T-cell transcription factor NFAT5; TonE-binding protein; Tonicity-responsive enhancer-binding protein
基因别名: KIAA0827; NF-AT5; NFAT5; NFATL1; NFATZ; OREBP; TONEBP
UniProt ID: (Human) O94916
Entrez Gene ID: (Human) 10725
