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产品信息
PEP-1136
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 16 amino acids near the amino terminus of human NALP6.
PEP-1136 can be used as a blocking peptide with polyclonal antibody PA5-21022.
靶标信息
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NLR family, pyrin domain containing 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYRIN-containing APAF1-like protein 5
基因别名: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) A8K9F3
Entrez Gene ID: (Human) 171389
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
G-protein coupled receptor signaling pathway
response to bacterium
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
regulation of mucus secretion
negative regulation of ERK1 and ERK2 cascade
