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产品信息
PEP-1131
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 18 amino acids near the amino terminus of human NOD4.
PEP-1131 can be used as a blocking peptide with polyclonal antibody PA5-21017.
靶标信息
NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kappa-B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Caterpiller protein 16.1; CLR16.1; NLR family, CARD domain containing 5; NOD-like receptor C5; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5
基因别名: CLR16.1; NLRC5; NOD27; NOD4
UniProt ID: (Human) Q86WI3
Entrez Gene ID: (Human) 84166
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
regulation of kinase activity
innate immune response
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
positive regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway
