Invitrogen

Human NPC1 Synthetic Peptide

产品信息

PEP-0867

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 15 amino acids near the carboxy terminus of human NPC1.

PEP-0867 can be used as a blocking peptide with polyclonal antibody PA5-20753.

靶标信息

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: FLJ98532; Niemann-Pick C1 protein; Niemann-Pick disease, type C1; NPC intracellular cholesterol transporter 1; truncated Niemann-Pick C1

基因别名: NPC; NPC1

UniProt ID: (Human) Q9P130

Entrez Gene ID: (Human) 4864

功能

protein glycosylation endocytosis autophagy lysosomal transport signal transduction adult walking behavior cholesterol metabolic process bile acid metabolic process negative regulation of macroautophagy cholesterol transport membrane raft organization cholesterol efflux response to drug cholesterol homeostasis response to cadmium ion viral entry into host cell negative regulation of cell death cellular response to steroid hormone stimulus cellular response to low-density lipoprotein particle stimulus establishment of protein localization to membrane positive regulation of cholesterol homeostasis

参与通路

virus receptor activity receptor activity transmembrane signaling receptor activity protein binding sterol transporter activity cholesterol binding

Human NPC1 Synthetic Peptide

产品信息

PEP-0867

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

性能保障

随时为您服务

Your items have has been added!