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产品信息
PEP-0699
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 15 amino acids near the amino terminus of human PARL
PEP-0699 can be used as a blocking peptide with polyclonal antibody PA5-20579.
靶标信息
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; P-beta; Pbeta; Presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
基因别名: PARL; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300
Entrez Gene ID: (Human) 55486
分子生物学功能:
serine protease
proteolysis
protein processing
regulation of proteolysis
membrane protein proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein targeting to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
