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产品信息
PEP-0818
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 17 amino acids near the amino terminus of human PCDH12.
PEP-0818 can be used as a blocking peptide with polyclonal antibody PA5-20703.
靶标信息
Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.
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生物信息学
蛋白别名: Protocadherin-12; Protocadherin-12, secreted form; Vascular cadherin-2; vascular endothelial cadherin 2; Vascular endothelial cadherin-2; VE-cad-2; VE-cadherin 2
基因别名: PCDH12; UNQ395/PRO731; VE-cadherin-2; VECAD2
UniProt ID: (Human) Q9NPG4
Entrez Gene ID: (Human) 51294
分子生物学功能:
cadherin
