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产品信息
PEP-0798
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 21 amino acids near the carboxy terminus of human PDCD5.
PEP-0798 can be used as a blocking peptide with polyclonal antibody PA5-20682.
靶标信息
Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Programmed cell death protein 5; Protein TFAR19; TF-1 cell apoptosis-related protein 19; TF1 cell apoptosis-related gene 19; TFAR19 novel apoptosis-related
基因别名: PDCD5; TFAR19
UniProt ID: (Human) O14737
Entrez Gene ID: (Human) 9141
分子生物学功能:
protein-binding activity modulator
apoptotic process
negative regulation of cell proliferation
positive regulation of gene expression
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to transforming growth factor beta stimulus
positive regulation of release of cytochrome c from mitochondria
positive regulation of protein import into mitochondrial outer membrane
negative regulation of chaperone-mediated protein folding
