Invitrogen

Human PHAP Synthetic Peptide

产品信息

PEP-0145

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to amino acids near the carboxy terminus of human PHAP.

PEP-0145 can be used as a blocking peptide with polyclonal antibody PA5-20026.

靶标信息

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic leucine-rich nuclear phosphoprotein 32 family member E; Acidic nuclear phosphoprotein pp32; Acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; LANP; LANP-L; LANP-like protein; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein like; Mapmodulin; PHAPI; PHAPI2; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; Putative HLA-DR-associated protein I; Putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; Silver-stainable protein SSP29

基因别名: ANP32A; ANP32B; ANP32E; APRIL; C15orf1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; PHAP1; PHAPI; PHAPI2; PP32; SSP29

UniProt ID: (Human) P39687, (Human) Q92688, (Human) Q9BTT0

Entrez Gene ID: (Human) 8125, (Human) 10541, (Human) 81611

分子生物学功能: chromatin/chromatin-binding, or -regulatory protein